Dandelion (Taraxacum mongolicum Hand.-Mazz.) suppresses the decrease in physical strength and exercise capacity caused by insufficient liver function

Abstract In this study, D-galactose was used to establish a model of liver dysfunction caused by oxidative stress in mice, and the effect dandelion on improving exercise capacity mice with observed its mechanism expounded. This study examined role running ability, swimming endurance, blood biochemical indices, histopathological changes, tissue mRNA expression changes. The animal results showed that extended time exhaustion dysfunctional reduced serum levels urea nitrogen (BUN), lactic acid (BLA) malondialdehyde (MDA) liver, increased hepatic glycogen (HG) muscle (MG) as well uperoxide dismutase (SOD) glutathione peroxidase (GSH-Px) activities. Histopathological observations suggested alleviated lesions liver. quantitative polymerase chain reaction (qPCR) analysis downregulated inducible nitric oxide synthase (iNOS) tumor necrosis factor-alpha (TNF-α) neuronal (nNOS), copper/zinc-superoxide (Cu/Zn-SOD), manganese-superoxide (Mn-SOD), catalase (CAT) skeletal liver-dysfunctional mice. contrast, syncytin-1 dysregulated positional main components were gallic acid, protocatechuic chlorogenic caffeic p-coumaric rutin, myricitrin, isoquercitrin, isochlorogenic A, luteolin.